Giovanna Lombardi is the Professor of Human Immunology at King’s College London. The research in her laboratory has focused on the mechanisms of transplant rejection and tolerance and on the phenotype and function of naturally occurring regulatory T cells (Tregs). She has developed a protocol to expand polyclonal Tregs that are currently in use as part of a large EU cell therapy consortium and in close collaboration with Kathryn Wood in Oxford and in a second Phase 1 clinical trial for the treatment of patients receiving a liver transplant. In parallel, Giovanna’s group have demonstrated using pre-clinical models that adoptive cell therapy using regulatory T cells specific for the graft offers an advantage compared to polyclonal Tregs in preventing chronic allograft rejection. A grant application for a new clinical trial has been submitted to study graft-specific Tregs in liver transplant patients.
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